Primary Epstein-Barr virus infection does not erode preexisting CD8+ T cell memory in humans
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چکیده
منابع مشابه
Primary Epstein-Barr virus infection does not erode preexisting CD8+ T cell memory in humans
Acute Epstein-Barr virus (EBV) infection results in an unusually robust CD8(+) T cell response in young adults. Based on mouse studies, such a response would be predicted to result in attrition of preexisting memory to heterologous infections like influenza A (Flu) and cytomegalovirus (CMV). Furthermore, many studies have attempted to define the lymphocytosis that occurs during acute EBV infect...
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One of the intriguing and largely unexplained features of primary Epstein-Barr virus (EBV) infection in humans is that only a small proportion of individuals display the clinical symptoms of acute infectious mononucleosis (IM).1 Previous studies have proposed a role for a number of potential factors in controlling the symptoms of primary EBV infection, such as viral load and cytokine dysregulat...
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Introduction: Epstein – Barr virus (EBV) is a herpesvirus which establishes a persistent life-long infection in over 95% of adults world wide. Infection is usually asymptomatic but the virus is associated with a variety of disease, including nasopharyngeal carcinoma (NPC), Burkitt’s lymphoma (BL), Multiple sclerosis MS, EBV-associated B-cell lymphoproliferative disease (BLPD), Hodgkin and non...
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Primary virus infection often elicits a large CD8(+) T cell response which subsequently contracts to a smaller memory T cell pool; the relationship between these two virus-specific populations is not well understood. Here we follow the human CD8(+) T cell response to Epstein-Barr virus (EBV) from its primary phase in infectious mononucleosis (IM) through to the persistent carrier state. Using H...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2012
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.20112401